444151 InSolution™ Nutlin-3, Racemic - Calbiochem

444151
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₀H₃₀Cl₂N₄O₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444151-1MG
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      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 1 mg
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          Description
          Catalogue Number444151
          Brand Family Calbiochem®
          Synonyms MDM2 Inhibitor IV
          References
          ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.
          Product Information
          FormLiquid
          FormulationA 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
          Hill FormulaC₃₀H₃₀Cl₂N₄O₄
          Chemical formulaC₃₀H₃₀Cl₂N₄O₄
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444151

          References

          Reference overview
          Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-August-2008 JSW
          Synonyms MDM2 Inhibitor IV
          DescriptionA cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
          FormLiquid
          FormulationA 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₀H₃₀Cl₂N₄O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.