444968 InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

444968
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₄F₃IN₂O₄ 391210-10-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444968-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
          Catalogue Number444968
          Brand Family Calbiochem®
          SynonymsPD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
          References
          ReferencesBarrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
          Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
          Silva, J., et al. 2008. PLoS Biol. 6, 2237.
          Ying, Q.L., et al. 2008. Nature 453, 519.
          Bain, J., et al. 2007. Biochem. J. 408, 297.
          Solit, D.B., et al. 2006. Nature 439, 358.
          Product Information
          CAS number391210-10-9
          FormLiquid
          FormulationA 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
          Hill FormulaC₁₆H₁₄F₃IN₂O₄
          Chemical formulaC₁₆H₁₄F₃IN₂O₄
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          ApplicationInSolution™ MEK1/2 Inhibitor III, PD0325901, CAS 391210-10-9, is a 50 mM solution of MEK1/2 Inhibitor III, PD0325901 in DMSO. A cell-permeable, potent, non-competitive MEK/MAPKK/MKK inhibitor.
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Regulatory Review
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444968

          References

          Reference overview
          Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
          Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
          Silva, J., et al. 2008. PLoS Biol. 6, 2237.
          Ying, Q.L., et al. 2008. Nature 453, 519.
          Bain, J., et al. 2007. Biochem. J. 408, 297.
          Solit, D.B., et al. 2006. Nature 439, 358.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2012 JSW
          SynonymsPD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
          DescriptionA cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
          FormLiquid
          FormulationA 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number391210-10-9
          Chemical formulaC₁₆H₁₄F₃IN₂O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Regulatory Review
          ReferencesBarrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
          Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
          Silva, J., et al. 2008. PLoS Biol. 6, 2237.
          Ying, Q.L., et al. 2008. Nature 453, 519.
          Bain, J., et al. 2007. Biochem. J. 408, 297.
          Solit, D.B., et al. 2006. Nature 439, 358.