401484 InSolution™ IKK-2 Inhibitor IV - Calbiochem

401484
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₂H₁₀FN₃O₂S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401484-500UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 500 μg
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          Description
          Catalogue Number401484
          Brand Family Calbiochem®
          References
          ReferencesPodolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
          Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
          Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.
          Product Information
          ATP CompetitiveY
          FormClear pale yellow Liquid
          FormulationA 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
          Hill FormulaC₁₂H₁₀FN₃O₂S
          Chemical formulaC₁₂H₁₀FN₃O₂S
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIKK-2
          Primary Target IC<sub>50</sub>18 nM
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401484

          References

          Reference overview
          Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
          Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
          Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.

          Brochure

          Title
          In Solution!" Product Flyer
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          DescriptionIKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC50 = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).
          FormClear pale yellow Liquid
          FormulationA 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₂H₁₀FN₃O₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Toxicity Irritant
          ReferencesPodolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
          Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
          Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.