400092 | InSolution™ HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

400092
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₂₉NO₅ 934593-90-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400092-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
          Catalogue Number400092
          Brand Family Calbiochem®
          SynonymsHypoxia-Inducible Factor-1 Inhibitor, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester
          References
          ReferencesNaik, R., et. al. 2012. J. Med. Chem. 55, 10564.
          Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
          Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
          Product Information
          CAS number934593-90-5
          FormLiquid
          FormulationA 25 mM (5 mg/459 µL) solution of HIF-1 Inhibitor (Cat. No. 400083) in DMSO.
          Hill FormulaC₂₆H₂₉NO₅
          Chemical formulaC₂₆H₂₉NO₅
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHIF-1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Naik, R., et. al. 2012. J. Med. Chem. 55, 10564.
          Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
          Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-February-2013 JSW
          SynonymsHypoxia-Inducible Factor-1 Inhibitor, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester
          DescriptionA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
          FormLiquid
          FormulationA 25 mM (5 mg/459 µL) solution of HIF-1 Inhibitor (Cat. No. 400083) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number934593-90-5
          Chemical formulaC₂₆H₂₉NO₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesNaik, R., et. al. 2012. J. Med. Chem. 55, 10564.
          Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
          Lee, K., et al. 2007. J. Med. Chem. 50, 1675.