328010 InSolution™ ERK Inhibitor II, FR180204 - Calbiochem

328010
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₁₃N₇

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      328010-500UG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 500 μg
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          Description
          OverviewA cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 of 3.1 µM). ERK Inhibitor II, Negative Control (Cat. No. 328008) and the solid form of this compound (Cat. No. 328007) are also available..
          Catalogue Number328010
          Brand Family Calbiochem®
          References
          ReferencesOhori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
          Product Information
          FormLiquid
          FormulationA 10 mM (500 µg/153 µl) solution of ERK Inhibitor II, FR180204 (Cat. No. 328007) in DMSO.
          Hill FormulaC₁₈H₁₃N₇
          Chemical formulaC₁₈H₁₃N₇
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          328010

          References

          Reference overview
          Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-January-2012 RFH
          DescriptionA cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 of 3.1 µM). ERK Inhibitor II, Negative Control is also available (Cat. No. 328008).
          FormLiquid
          FormulationA 10 mM (500 µg/153 µl) solution of ERK Inhibitor II, FR180204 (Cat. No. 328007) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₁₃N₇
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesOhori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.