239806 | InSolution™ Cyclopamine, V. californicum - Calbiochem

239806
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₇H₄₁NO₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239806-5MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
          Catalogue Number239806
          Brand Family Calbiochem®
          SynonymsShh Signaling Antagonist I in EtOH
          References
          ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
          Thayer, S.P., et al. 2003. Nature, 425, 851.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.
          Product Information
          FormLiquid
          FormulationSupplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
          Hill FormulaC₂₇H₄₁NO₂
          Chemical formulaC₂₇H₄₁NO₂
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 10

          Flammable.
          S PhraseS: 16-7

          Keep away from sources of ignition - No Smoking.
          Keep container tightly closed.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Flammable
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          239806

          References

          Reference overview
          Berman, D.M., et al. 2003. Nature, 425, 846.
          Thayer, S.P., et al. 2003. Nature, 425, 851.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-June-2012 JSW
          SynonymsShh Signaling Antagonist I in EtOH
          DescriptionA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
          FormLiquid
          FormulationSupplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₇H₄₁NO₂
          Structure formulaStructure formula
          Purity≥97% by NMR
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Flammable
          ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
          Thayer, S.P., et al. 2003. Nature, 425, 851.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.