197334 | InSolution™ Bcl-2 Inhibitor VI, ABT-737 - Calbiochem

197334
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₂H₄₅ClN₆O₅S₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      197334-5MG
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          Glass bottle 5 mg
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          Description
          Catalogue Number197334
          Brand Family Calbiochem®
          Synonyms(R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide, 4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide
          References
          ReferencesBardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
          Oltersdorf, T., et al. 2005. Nature 435, 677.
          Product Information
          FormLiquid
          FormulationA 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
          Hill FormulaC₄₂H₄₅ClN₆O₅S₂
          Chemical formulaC₄₂H₄₅ClN₆O₅S₂
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetBcl-2 family members
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          197334

          References

          Reference overview
          Bardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
          Oltersdorf, T., et al. 2005. Nature 435, 677.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2014 JSW
          Synonyms(R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide, 4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide
          DescriptionA cell-permeable nitrophenylsulfonylbenzamide compound that is shown to bind anti-apoptotic Bcl-2 family members Bcl-2, Bcl-XL, and Bcl-w with high affinity (Ki ≤1 nM) and serves as a nonpeptidyl alternative to Bad-derived BH3 peptide (Cat. No. 197220) in preventing the binding and inhibition of the pro- apoptotic by the anti-apoptotic Bcl-2 family proteins. ABT-737 is demonstrated to fully reverse the blockage of Myr-Bid-induced cytochrome c release by Bcl-2 in mitochondria preparations from Bcl-2 overexpressing FL5.12 cells and effectively inhibit the growth of numerous cancer cells both in cultures in vitro (IC50 ≤100 nM against H146 and H1963) and in vivo (complete regression of H146 and H1963 in xenograft mice at 100 mg/kg/day, i.p.). Application of ABT-737 is also demonstrated to significantly reduce the disease severity in several murine models of autoimmunity.
          FormLiquid
          FormulationA 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₂H₄₅ClN₆O₅S₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
          Toxicity Standard Handling
          ReferencesBardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
          Oltersdorf, T., et al. 2005. Nature 435, 677.