171261 | InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

171261
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₅N₅O 866405-64-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      171261-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo.
          Catalogue Number171261
          Brand Family Calbiochem®
          SynonymsDorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
          References
          ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
          Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
          Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
          Inoki, K., et al. 2003. Cell 115, 577.
          Fryer, L.G., 2002. FEBS Lett. 531, 189.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
          Product Information
          CAS number866405-64-3
          ATP CompetitiveY
          FormLiquid
          FormulationSupplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
          Hill FormulaC₂₄H₂₅N₅O
          Chemical formulaC₂₄H₂₅N₅O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAMPK
          Primary Target IC<sub>50</sub>25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
          Primary Target K<sub>i</sub>EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          171261

          References

          Reference overview
          Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.
          Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
          Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
          Inoki, K., et al. 2003. Cell 115, 577.
          Fryer, L.G., 2002. FEBS Lett. 531, 189.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Calbiochem Biologics 32.2
          In Solution!" Product Flyer
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-March-2012 JSW
          SynonymsDorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
          DescriptionA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo.
          FormLiquid
          FormulationSupplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number866405-64-3
          Chemical formulaC₂₄H₂₅N₅O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
          Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
          Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
          Inoki, K., et al. 2003. Cell 115, 577.
          Fryer, L.G., 2002. FEBS Lett. 531, 189.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.