500583 InSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem

500583
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₂₄O₄ 20350-15-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.00583.0001
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          Glass bottle 2 mg
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          Description
          Catalogue Number500583
          Brand Family Calbiochem®
          Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein
          References
          ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
          Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
          Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
          Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
          Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
          Ktistakis, N.Y., et al. 1992. Nature 356, 344.
          Product Information
          CAS number20350-15-6
          FormLiquid
          FormulationA 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO.
          Hill FormulaC₁₆H₂₄O₄
          Chemical formulaC₁₆H₂₄O₄
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetADP-ribosylation factor (ARF)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
          Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
          Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
          Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
          Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
          Ktistakis, N.Y., et al. 1992. Nature 356, 344.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-July-2014 JSW
          Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein
          DescriptionSpecifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange.
          FormLiquid
          FormulationA 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number20350-15-6
          Chemical formulaC₁₆H₂₄O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use.
          Toxicity Irritant
          ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
          Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
          Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
          Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
          Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
          Ktistakis, N.Y., et al. 1992. Nature 356, 344.