401020 | Imiquimod - CAS 99011-02-6 - Calbiochem

401020
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₆N₄ 99011-02-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401020-250MG
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          Plastic ampoule 250 mg
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          Description
          OverviewAn imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.
          Catalogue Number401020
          Brand Family Calbiochem®
          Synonyms1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
          References
          ReferencesMajewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
          Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
          Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
          Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.
          Product Information
          CAS number99011-02-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₄H₁₆N₄
          Chemical formulaC₁₄H₁₆N₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTLR7 (toll-like receptor 7)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25-36/37/38

          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401020

          References

          Reference overview
          Majewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
          Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
          Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
          Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-May-2009 JSW
          Synonyms1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
          DescriptionAn imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number99011-02-6
          Chemical formulaC₁₄H₁₆N₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (3 mg/ml); warming to 60°C is required for complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.
          Toxicity Toxic
          ReferencesMajewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
          Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
          Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
          Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.