401474 IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

IKK Inhibitor II, Wedelolactone, CAS 524-12-9, is a cell-permeable, selective, irreversible inhibitor of IKKα and β kinase activity (IC50 = 10 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Wedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan

Primary Target: IKKα and β kinase activity
401474
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₀O₇ 524-12-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401474-1MG
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          		 Plastic ampoule 1 mg
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          Description
          OverviewThe naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.
          Catalogue Number401474
          Brand Family Calbiochem®
          SynonymsWedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
          References
          ReferencesKobori, M., et al. 2004. Cell Death Differ. 11, 123.
          Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
          Mors, W.B., et al. 1989. Toxicon 27, 1003.
          Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.
          Product Information
          CAS number524-12-9
          ATP CompetitiveN
          FormYellowish-green, crystalline powder
          Hill FormulaC₁₆H₁₀O₇
          Chemical formulaC₁₆H₁₀O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationIKK Inhibitor II, Wedelolactone, CAS 524-12-9, is a cell-permeable, selective, irreversible inhibitor of IKKα and β kinase activity (IC50 = 10 µM).
          Biological Information
          Primary TargetIKKα and β kinase activity
          Primary Target IC<sub>50</sub>< 10 µM against IKKα and β kinase activity
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401474

          References

          Reference overview
          Kobori, M., et al. 2004. Cell Death Differ. 11, 123.
          Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
          Mors, W.B., et al. 1989. Toxicon 27, 1003.
          Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-October-2009 RFH
          SynonymsWedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
          DescriptionCell-permeable. The naturally-occuring active ingredient from the herbal medicine, Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC50 < 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.
          FormYellowish-green, crystalline powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number524-12-9
          Chemical formulaC₁₆H₁₀O₇
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or Methanol (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKobori, M., et al. 2004. Cell Death Differ. 11, 123.
          Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
          Mors, W.B., et al. 1989. Toxicon 27, 1003.
          Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.