401479 | IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

401479
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₈N₂OS₂ 354812-17-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401479-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 = ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401485) in DMSO is also available.
          Catalogue Number401479
          Brand Family Calbiochem®
          SynonymsSC-514
          References
          ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
          Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
          Product Information
          CAS number354812-17-2
          ATP CompetitiveY
          FormPale yellow solid
          Hill FormulaC₉H₈N₂OS₂
          Chemical formulaC₉H₈N₂OS₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIKK-2
          Primary Target IC<sub>50</sub>3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401479

          References

          Reference overview
          Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
          Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsSC-514
          DescriptionA cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number354812-17-2
          Chemical formulaC₉H₈N₂OS₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
          Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.