401006 Hypoestoxide, Hypoestes rosea - Calbiochem

401006
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₃₂O₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401006-1MG
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      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 1 mg
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          Description
          OverviewA naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells, thereby preventing NF-κB activation. Also inhibits the production of nitric oxide by IL-1β or IL-17 stimulated normal human chondrocytes. Reported to neither affect the synthesis of prostaglandin nor inhibit the activities of JNK and p38MAPK.
          Catalogue Number401006
          Brand Family Calbiochem®
          References
          ReferencesPulai, J.I., et al. 2005. J. Immunol. 174, 5781.
          Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
          Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₂H₃₂O₅
          Chemical formulaC₂₂H₃₂O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIKB Kinase
          Primary Target IC<sub>50</sub>24 µM against IκB kinase
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401006

          References

          Reference overview
          Pulai, J.I., et al. 2005. J. Immunol. 174, 5781.
          Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
          Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          DescriptionA naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells thereby prevents NF-κB activation. Also inhibits the production of nitric oxide in IL-1β or IL-17 stimulated normal human chondrocytes. Does not inhibit the activities of JNK and p38MAPK. Reported to be effective against murine blood and liver stages of malarial parasites. Inhibits VEGF-induced cell proliferation in vitro (IC50 = 28.6 µM) and bFGF-induced angiogenesis in the chick chorioallantoic membrane (IC50 = 10 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₃₂O₅
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (3 mg/ml) (slight warming may be required) or Ethanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C.
          Toxicity Harmful
          ReferencesPulai, J.I., et al. 2005. J. Immunol. 174, 5781.
          Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
          Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.