400076 | Hypericin - CAS 548-04-9 - Calbiochem

400076
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₀H₁₆O₈ 548-04-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400076-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewPolycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 μM). Also known to inhibit casein kinase II (IC50 = 6 nM), MAP kinase (IC50 = 4 nM), and the protein tyrosine activities of the insulin receptor (IC50 = 20-29 nM) and the epidermal growth factor receptor (IC50 = 35 nM).
          Catalogue Number400076
          Brand Family Calbiochem®
          SynonymsCasein Kinase II Inhibitor XI
          References
          ReferencesZhang, W., et al. 1997. Cancer Lett. 120, 31.
          Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
          Frew, T., et al. 1994. Anticancer Res. 14, 2425.
          Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
          Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.
          Product Information
          CAS number548-04-9
          ATP CompetitiveN
          FormBlack solid
          Hill FormulaC₃₀H₁₆O₈
          Chemical formulaC₃₀H₁₆O₈
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>3.3 µM, 6 nM, 4 nM, 20-29 nM , 35 nM, against protein kinase C, casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor, and the epidermal growth factor receptor, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          400076

          References

          Reference overview
          Zhang, W., et al. 1997. Cancer Lett. 120, 31.
          Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
          Frew, T., et al. 1994. Anticancer Res. 14, 2425.
          Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
          Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.

          Brochure

          Title
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-December-2015 JSW
          SynonymsCasein Kinase II Inhibitor XI
          DescriptionPolycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 µM). Also known to inhibit the protein tyrosine kinase activities of the insulin receptor (IC50 = 20-29 nM), the epidermal growth factor receptor (IC50 = 35 nM), casein kinase II (IC50 = 6 nM), and MAP kinase (IC50 = 4 nM). Useful probe for PKC due to its bright red fluorescence emission and photostability. Also see Pseudohypericin (Cat. No. 539590).
          FormBlack solid
          CAS number548-04-9
          Chemical formulaC₃₀H₁₆O₈
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml), Ethanol (1 mg/ml) or Methanol (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 4863
          ReferencesZhang, W., et al. 1997. Cancer Lett. 120, 31.
          Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
          Frew, T., et al. 1994. Anticancer Res. 14, 2425.
          Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
          Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.