3779 Histamine, Free Base - CAS 51-45-6 - Calbiochem

3779
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅H₉N₃ 51-45-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      3779-1GM
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          Glass bottle 1 gm
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          3779-5GM
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              Plastic ampoule 5 gm
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              Description
              OverviewA potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H1 receptors leads to Ca2+ mobilization, whereas histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.
              Catalogue Number3779
              Brand Family Calbiochem®
              Synonyms2-(4-Imidazolyl)ethylamine
              References
              ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
              Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
              Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
              Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
              Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
              Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
              Product Information
              CAS number51-45-6
              FormWhite solid
              Hill FormulaC₅H₉N₃
              Chemical formulaC₅H₉N₃
              Hygroscopic Hygroscopic
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Purity≥97% by TLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSMS1050000
              Safety Information
              R PhraseR: 22-36/37/38-42/43

              Harmful if swallowed.
              Irritating to eyes, respiratory system and skin.
              May cause sensitization by inhalation and skin contact.
              S PhraseS: 26-36/37-22

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing and gloves.
              Do not breathe dust.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              3779

              References

              Reference overview
              Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
              Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
              Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
              Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
              Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
              Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.

              Brochure

              Title
              Nitric Oxide and Oxidative Stress Brochure
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision21-June-2011 JSW
              Synonyms2-(4-Imidazolyl)ethylamine
              DescriptionA potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number51-45-6
              RTECSMS1050000
              Chemical formulaC₅H₉N₃
              Structure formulaStructure formula
              Purity≥97% by TLC
              SolubilityH₂O (1 mg/ml)
              Storage +2°C to +8°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Harmful
              Merck USA index14, 4719
              ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
              Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
              Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
              Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
              Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
              Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.