373277 | Hh Signaling Antagonist XI, MRT-14 - Calbiochem

373277
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₄H₂₃N₃O₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      373277-10MG
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      Stocked 
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 & 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).
          Catalogue Number373277
          Brand Family Calbiochem®
          SynonymsN-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII
          References
          ReferencesManetti, F., et al. 2010. Mol. Pharmacol. 78, 658.
          Product Information
          FormWhite powder
          Hill FormulaC₂₄H₂₃N₃O₆
          Chemical formulaC₂₄H₂₃N₃O₆
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          373277

          References

          Reference overview
          Manetti, F., et al. 2010. Mol. Pharmacol. 78, 658.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-October-2012 JSW
          SynonymsN-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII
          DescriptionA cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 and 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₄H₂₃N₃O₆
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesManetti, F., et al. 2010. Mol. Pharmacol. 78, 658.