375670 | Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem

375670
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₀H₄₂N₂O₉ 70563-58-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      375670-100UG
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          Glass bottle 100 μg
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          Description
          OverviewA potent and cell-permeable protein tyrosine kinase inhibitor. Inhibits p60v-src (IC50 = 12 µM) and PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Reported to inhibit c-Src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane. Also shown to inhibit anti-CD3 monoclonal antibody-induced apoptosis of thymocytes.
          Catalogue Number375670
          Brand Family Calbiochem®
          References
          ReferencesFan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
          Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
          Migita, K., et al. 1994. J. Immunol. 153, 3457.
          Okabe, M., et al. 1994. Leuk. Res. 18, 867.
          Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
          Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
          Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
          Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
          Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
          Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
          Uehara, Y., et al. 1988. Virology 164, 294.
          Omura, S., et al. 1979. J. Antibiotics 32, 255.
          Product Information
          CAS number70563-58-5
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₃₀H₄₂N₂O₉
          Chemical formulaC₃₀H₄₂N₂O₉
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP60v-src
          Primary Target IC<sub>50</sub>12 µM against P60v-src
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLX8930000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          375670

          References

          Reference overview
          Fan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
          Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
          Migita, K., et al. 1994. J. Immunol. 153, 3457.
          Okabe, M., et al. 1994. Leuk. Res. 18, 867.
          Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
          Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
          Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
          Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
          Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
          Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
          Uehara, Y., et al. 1988. Virology 164, 294.
          Omura, S., et al. 1979. J. Antibiotics 32, 255.

          Citations

          Title
        • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
        • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-July-2008 RFH
          DescriptionA cell-permeable, potent inhibitor of protein tyrosine kinases. Inhibits p60v-src (IC50 = 12 µM) autophosphorylation. Irreversibly binds to the sulfhydryl groups of the kinase. Dose-dependently inhibits PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Also, reported to inhibit c-src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane and blocks anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Several mammalian cell lines transformed with tyrosine kinase oncogenes (src, abl, fps, ros, yes, erbB) show reversion from the transformed to the normal phenotype after treatment with herbimycin A.
          FormYellow solid
          CAS number70563-58-5
          RTECSLX8930000
          Chemical formulaC₃₀H₄₂N₂O₉
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml). Further dilute with H₂O or aqueous buffers just prior to use.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesFan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
          Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
          Migita, K., et al. 1994. J. Immunol. 153, 3457.
          Okabe, M., et al. 1994. Leuk. Res. 18, 867.
          Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
          Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
          Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
          Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
          Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
          Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
          Uehara, Y., et al. 1988. Virology 164, 294.
          Omura, S., et al. 1979. J. Antibiotics 32, 255.
          Citation
        • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
        • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.