203820 | Guanosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem

203820
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₀BrN₅O₇P · Na 51116-01-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203820-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewCell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.
          Catalogue Number203820
          Brand Family Calbiochem®
          Synonyms8-Bromo-cGMP, Br-cGMP, Na
          References
          ReferencesKwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
          Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
          Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
          Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.
          Product Information
          CAS number51116-01-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₁₀BrN₅O₇P · Na
          Chemical formulaC₁₀H₁₀BrN₅O₇P · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetprotein kinase G
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203820

          References

          Reference overview
          Kwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
          Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
          Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
          Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.

          Brochure

          Title
          Nucleotides and Bases Technical Bulletin

          Citations

          Title
        • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-May-2008 RFH
          Synonyms8-Bromo-cGMP, Br-cGMP, Na
          DescriptionCell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number51116-01-9
          Chemical formulaC₁₀H₁₀BrN₅O₇P · Na
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (200 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.
          Toxicity Standard Handling
          ReferencesKwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
          Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
          Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
          Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.
          Citation
        • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.