368050 | Granzyme B Inhibitor I - Calbiochem

368050
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₉H₂₄ClN₃O₇

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      368050-1MG
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      Stocked 
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          Plastic ampoule 1 mg
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          Description
          OverviewA weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
          Catalogue Number368050
          Brand Family Calbiochem®
          SynonymsZ-AAD-CMK
          References
          ReferencesGong, B., et al. 1999. Cell Growth Different. 10, 491.
          Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
          Odake, S., et al. 1991. Biochemistry 30, 2217.
          Product Information
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₉H₂₄ClN₃O₇
          Chemical formulaC₁₉H₂₄ClN₃O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGranzyme B
          Primary Target IC<sub>50</sub>300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Ala-Ala-Asp-CH₂Cl
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          368050

          References

          Reference overview
          Gong, B., et al. 1999. Cell Growth Different. 10, 491.
          Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
          Odake, S., et al. 1991. Biochemistry 30, 2217.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-July-2008 RFH
          SynonymsZ-AAD-CMK
          DescriptionA weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
          FormOff-white solid
          Chemical formulaC₁₉H₂₄ClN₃O₇
          Peptide SequenceZ-Ala-Ala-Asp-CH₂Cl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGong, B., et al. 1999. Cell Growth Different. 10, 491.
          Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
          Odake, S., et al. 1991. Biochemistry 30, 2217.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Granzyme Inhibitors