361515 | Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem

361515
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₅ClF₂N₄O₄ 648926-15-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361515-1MG
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          Plastic ampoule 1 mg
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          361515-5MG
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              Glass bottle 5 mg
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              Description
              OverviewA cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.
              Catalogue Number361515
              Brand Family Calbiochem®
              Synonyms1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
              References
              ReferencesKlabunde, T., et al. 2005. J. Med. Chem. 48, 6178
              Product Information
              CAS number648926-15-2
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₁₇H₁₅ClF₂N₄O₄
              Chemical formulaC₁₇H₁₅ClF₂N₄O₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetGlycogen phosphorylase
              Primary Target IC<sub>50</sub>53 nM against glycogen phosphorylase
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              361515

              References

              Reference overview
              Klabunde, T., et al. 2005. J. Med. Chem. 48, 6178

              Brochure

              Title
              Biologics 32.4 ( 1.19 MB )
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision01-July-2008 RFH
              Synonyms1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
              DescriptionA cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number648926-15-2
              Chemical formulaC₁₇H₁₅ClF₂N₄O₄
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (25 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Irritant
              ReferencesKlabunde, T., et al. 2005. J. Med. Chem. 48, 6178