346006 | Glucagon-Like Peptide 1 Receptor Agonist - CAS 281209-71-0 - Calbiochem

346006
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₁₅Cl₂N₃O₂S 281209-71-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      346006-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50 = 101 nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin.
          Catalogue Number346006
          Brand Family Calbiochem®
          Synonyms6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline, GLP-1R Agonist
          References
          ReferencesKnudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.
          Product Information
          CAS number281209-71-0
          FormYellow solid
          Hill FormulaC₁₃H₁₅Cl₂N₃O₂S
          Chemical formulaC₁₃H₁₅Cl₂N₃O₂S
          Structure formula ImageStructure formula Image
          Applications
          ApplicationGlucagon-Like Peptide 1 Receptor Agonist, CAS 281209-71-0, modulates GLP-1 binding & induces cAMP production in BHK membranes. Potentiates glucose-dependent insulin release in WT pancreatic islets.
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          346006

          References

          Reference overview
          Knudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.

          Brochure

          Title
          Biologics 35.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2011 RFH
          Synonyms6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline, GLP-1R Agonist
          DescriptionA nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50 = 101 nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number281209-71-0
          Chemical formulaC₁₃H₁₅Cl₂N₃O₂S
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (20 mg/ml) or Ethanol (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesKnudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.