538096 GluN2B NMDA Receptor Antagonist, 93-31 - Calbiochem

538096
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₃₀Cl₂N₂O₄S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.38096.0001
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          Glass bottle 10 mg
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          Description
          OverviewA tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM).
          Catalogue Number538096
          Brand Family Calbiochem®
          Synonyms(S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
          References
          ReferencesYuan, H., et al. 2015. Neuron. 85, 1305.
          Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.
          Product Information
          FormLight yellow to yellow sticky solid
          Hill FormulaC₂₂H₃₀Cl₂N₂O₄S
          Chemical formulaC₂₂H₃₀Cl₂N₂O₄S
          ReversibleY
          Applications
          Biological Information
          Primary TargetGluN2B NMDA Receptor
          Primary Target IC<sub>50</sub>0.19 µ
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          GluN2B NMDA Receptor Antagonist, 93-31 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Yuan, H., et al. 2015. Neuron. 85, 1305.
          Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-July-2017 JSW
          Synonyms(S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
          DescriptionA tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM).
          FormLight yellow to yellow sticky solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₃₀Cl₂N₂O₄S
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYuan, H., et al. 2015. Neuron. 85, 1305.
          Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.