345872 | Glial Derived Neurotrophic Factor, Human, Recombinant, E. coli

345872
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥97% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345872-10UG
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      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 10 μg
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          Description
          OverviewRecombinant, human glial derived neutotrophic factor expressed in E. coli. A heterogeneously glycosylated growth promoting factor that enhances neuronal survival of dopaminergic midbrain neurons. Activates receptor tyrosine kinase Ret and promotes kidney morphogenesis. Also an activator of MAP kinase. Its biological activity is destroyed by reduction of disulfide bonds.
          Catalogue Number345872
          Brand Family Calbiochem®
          SynonymsrhGDNF
          References
          ReferencesVega, Q.C., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 10657.
          Worby, C.A., et al. 1996. J. Biol. Chem. 271, 23619.
          Lin, L.F., et al. 1994. J. Neurochem. 63, 758.
          Lev-Fen, H., et al. 1993. Science 260, 1130.
          Product Information
          FormLyophilized
          Applications
          Biological Information
          Biological activityfully biologically active when compared to native GDNF by dose-dependent ³H-dopamine uptake assay
          Purity≥97% by SDS-PAGE
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345872

          References

          Reference overview
          Vega, Q.C., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 10657.
          Worby, C.A., et al. 1996. J. Biol. Chem. 271, 23619.
          Lin, L.F., et al. 1994. J. Neurochem. 63, 758.
          Lev-Fen, H., et al. 1993. Science 260, 1130.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-June-2008 RFH
          SynonymsrhGDNF
          DescriptionRecombinant, human glial derived neutotrophic factor expressed in E. coli. Growth promoting factor that enhances neuronal survival of dopaminergic midbrain neurons. A heterogeneously glycosylated basic protein. Its biological activity is destroyed by the reduction of disulfide bonds.
          FormLyophilized
          Purity≥97% by SDS-PAGE
          Biological activityfully biologically active when compared to native GDNF by dose-dependent ³H-dopamine uptake assay
          SolubilityH₂O and most aqueous buffers. The recommended stock solution is 1 µg/100µl. For more dilute samples, add a stabilizing protein such as 0.1% BSA.
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesVega, Q.C., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 10657.
          Worby, C.A., et al. 1996. J. Biol. Chem. 271, 23619.
          Lin, L.F., et al. 1994. J. Neurochem. 63, 758.
          Lev-Fen, H., et al. 1993. Science 260, 1130.