345805 | Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem

345805
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₄₀N₂O₉ 30562-34-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345805-100UG
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          Plastic ampoule 100 μg
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          Description
          OverviewA benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. Geldanamycin has antiproliferative and antitumor effects. Rapidly depletes p185c-erbB2 protein tyrosine kinase in breast carcinoma cells. Binds to HSP90 and disrupts Raf1-HSP90 complex leading to destabilization of Raf1. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase activity. Also known to selectively destabilize mutated p53 protein from a number of breast, leukemia, and prostate cell lines.
          Catalogue Number345805
          Brand Family Calbiochem®
          References
          ReferencesVasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.
          Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.
          Schulte, T.W., et al. 1996. Mol. Cell. Biol. 16, 5839.
          Blagosklonny, M.V., et al. 1995. Oncogene 11, 933.
          Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
          Whitesell, L., et all. 1994. Proc. Natl. Acad. USA 91, 8324.
          Yamaki, H., et al. 1989. J. Antibiot. 42, 604.
          Uehara, Y., et al. 1984. Mol. Cell. Biol. 6, 2198.
          Product Information
          CAS number30562-34-6
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₉H₄₀N₂O₉
          Chemical formulaC₂₉H₄₀N₂O₉
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetpc60c-svc tyrosine kinase
          Primary Target IC<sub>50</sub>75 nM Inhibiting basal and hypoxia-induced expression of c-Jun
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLX8920000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345805

          References

          Reference overview
          Vasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.
          Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.
          Schulte, T.W., et al. 1996. Mol. Cell. Biol. 16, 5839.
          Blagosklonny, M.V., et al. 1995. Oncogene 11, 933.
          Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
          Whitesell, L., et all. 1994. Proc. Natl. Acad. USA 91, 8324.
          Yamaki, H., et al. 1989. J. Antibiot. 42, 604.
          Uehara, Y., et al. 1984. Mol. Cell. Biol. 6, 2198.

          Citations

          Title
        • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-June-2008 RFH
          DescriptionA benzoquinoid antibiotic that is a potent inhibitor of pp60src tyrosine kinase. Geldanamycin has antiproliferative and antitumor effects. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal Kinase activity. Binds to HSP90 and disrupts raf1-HSP90 complex leading to destabilizing of Raf1. Also destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits c-myc expression in murine lymphoblastoma cells. Approximately ten-fold more potent than herbimycin A (Cat. No. 375670).
          FormYellow solid
          CAS number30562-34-6
          RTECSLX8920000
          Chemical formulaC₂₉H₄₀N₂O₉
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesVasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.
          Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.
          Schulte, T.W., et al. 1996. Mol. Cell. Biol. 16, 5839.
          Blagosklonny, M.V., et al. 1995. Oncogene 11, 933.
          Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
          Whitesell, L., et all. 1994. Proc. Natl. Acad. USA 91, 8324.
          Yamaki, H., et al. 1989. J. Antibiot. 42, 604.
          Uehara, Y., et al. 1984. Mol. Cell. Biol. 6, 2198.
          Citation
        • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.