345752 Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk

345752
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₇₀H₁₂₃N₃O₃₀ · 2NH₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345752-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewHas been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
          Catalogue Number345752
          Brand Family Calbiochem®
          SynonymsNeu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
          References
          ReferencesDeMaria, R., et al. 1997. Science 277, 1652.
          Product Information
          FormWhite solid
          Hill FormulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
          Chemical formulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345752

          References

          Reference overview
          DeMaria, R., et al. 1997. Science 277, 1652.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-March-2008 JSW
          SynonymsNeu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
          DescriptionHas been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
          FormWhite solid
          Chemical formulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityChloroform:Methanol (2:1) or H₂O (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
          Toxicity Irritant
          ReferencesDeMaria, R., et al. 1997. Science 277, 1652.