345700 | Ganciclovir - CAS 82410-32-0 - Calbiochem

345700
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₁₃N₅O₄ 82410-32-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345700-50MG
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          Glass bottle 50 mg
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          Description
          OverviewA nucleoside analog structurally related to Acyclovir (Cat. No. 114798). Acts as a prodrug that is activated by phosphorylation. Has been used in the study of “suicide” gene therapy in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.
          Catalogue Number345700
          Brand Family Calbiochem®
          Synonyms9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
          References
          ReferencesAghi, M., et al. 2000. J. Gene Med. 2, 148.
          Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
          Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
          Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
          Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
          Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
          Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.
          Product Information
          CAS number82410-32-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₉H₁₃N₅O₄
          Chemical formulaC₉H₁₃N₅O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationGanciclovir, CAS 82410-32-0, is a nucleoside analog related to Acyclovir. Acts as a prodrug that is activated by phosphorylation. Inhibits the replication of cytomegalovirus (CMV; IC50 = 10 nM).
          Biological Information
          Primary TargetActs as a prodrug that is activated by phosphorylation
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMF8407000
          Safety Information
          R PhraseR: 46-60-61

          May cause heritable genetic damage.
          May impair fertility.
          May cause harm to the unborn child.
          S PhraseS: 36/37/39-45-53

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345700

          References

          Reference overview
          Aghi, M., et al. 2000. J. Gene Med. 2, 148.
          Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
          Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
          Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
          Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
          Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
          Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-November-2007 JSW
          Synonyms9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
          DescriptionA nucleoside analog that is structurally related to Acyclovir (Cat. No. 114798). Acts as a pro-drug that is activated by phosphorylation. It has been used in the study of "suicide gene therapy" in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus thymidine kinase (TK), the non-toxic pro-drug is converted to the phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the dividing malignant cells. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Has also been used to study the loss of telomers and to evaluate the sensitivity of viruses to anti-viral agents.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number82410-32-0
          RTECSMF8407000
          Chemical formulaC₉H₁₃N₅O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (2 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 4363
          ReferencesAghi, M., et al. 2000. J. Gene Med. 2, 148.
          Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
          Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
          Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
          Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
          Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
          Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.