361547 | GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem

361547
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆H₃Br₂ClOS 62673-69-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361547-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA thienyl α-chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
          Catalogue Number361547
          Brand Family Calbiochem®
          Synonyms2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
          References
          ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.
          Product Information
          CAS number62673-69-2
          ATP CompetitiveN
          FormOrange solid
          Hill FormulaC₆H₃Br₂ClOS
          Chemical formulaC₆H₃Br₂ClOS
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGsk-3β
          Primary Target IC<sub>50</sub>1 µM against Gsk-3β
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          361547

          References

          Reference overview
          Conde, S., et al. 2003. J. Med. Chem. 46, 4631.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          Synonyms2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
          DescriptionA cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number62673-69-2
          Chemical formulaC₆H₃Br₂ClOS
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml). Use fresh, anhydrous DMSO only.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
          Toxicity Standard Handling
          ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.