371818 G-Protein βγ Binding Peptide, mSIRK - Calbiochem

371818
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₉₃H₁₅₀N₂₀O₂₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371818-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          371818-5MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              Glass bottle 5 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
              Catalogue Number371818
              Brand Family Calbiochem®
              SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
              References
              ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
              Scott, J.K., et al. 2001. EMBO J. 20, 767.
              Product Information
              ATP CompetitiveN
              FormLyophilized
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₉₃H₁₅₀N₂₀O₂₅
              Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
              Hygroscopic Hygroscopic
              ReversibleN
              Applications
              Biological Information
              Primary TargetN-myristoylated G-protein βγ selective binding
              Primary Target IC<sub>50</sub>EC50 ~ 2.5 - 5 µM in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              371818

              References

              Reference overview
              Goubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
              Scott, J.K., et al. 2001. EMBO J. 20, 767.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision07-July-2008 RFH
              SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
              DescriptionA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange. Reported to cause a rapid activation of ERK1/2 (EC50 ~2.5-5 µM) in RASM (rat arterial smooth muscle) and Rat2 cells. Promotes the phosphorylation of JNK and p38 MAP kinase. Also increases phospholipase C activity and causes Ca2+ release from internal stores.
              FormLyophilized
              FormulationSupplied as a trifluoroacetate salt.
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
              Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
              Purity≥95% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage +2°C to +8°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
              Toxicity Standard Handling
              ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
              Scott, J.K., et al. 2001. EMBO J. 20, 767.