344930 Furin Inhibitor I - Calbiochem

344930
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₄H₆₆ClN₁₁O₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344930-150MG
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          Plastic ampoule 150 mg
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          344930-1MG
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              Plastic ampoule 1 mg
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              Description
              OverviewA peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
              Catalogue Number344930
              Brand Family Calbiochem®
              SynonymsDecanoyl-RVKR-CMK
              References
              ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
              Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
              Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
              Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
              Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
              Garten, W., et al. 1994. Biochimie 76, 217.
              Hallenberger, S., et al. 1992. Nature 360, 358.
              Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
              Product Information
              ATP CompetitiveN
              FormOff-white solid
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₃₄H₆₆ClN₁₁O₅
              Chemical formulaC₃₄H₆₆ClN₁₁O₅
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targetviral glycoproteins
              Purity≥90% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              344930

              References

              Reference overview
              Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
              Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
              Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
              Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
              Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
              Garten, W., et al. 1994. Biochimie 76, 217.
              Hallenberger, S., et al. 1992. Nature 360, 358.
              Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision27-June-2008 RFH
              SynonymsDecanoyl-RVKR-CMK
              DescriptionA peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
              FormOff-white solid
              FormulationSupplied as a trifluoroacetate salt.
              Chemical formulaC₃₄H₆₆ClN₁₁O₅
              Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
              Structure formulaStructure formula
              Purity≥90% by HPLC
              SolubilityDMSO or Methanol (1 mg/ml)
              Storage -20°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Standard Handling
              ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
              Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
              Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
              Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
              Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
              Garten, W., et al. 1994. Biochimie 76, 217.
              Hallenberger, S., et al. 1992. Nature 360, 358.
              Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.