344932 Furin, Human, Recombinant

344932
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344932-50UL
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Will advise
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          Plastic ampoule 50 ul
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          Description
          OverviewRecombinant, human furin expressed in vaccinia virus (VV:hFUR713t) infected BSC-40 cells. Supplied as a crude preparation of soluble furin obtained from cytoplasmic extracts. Furin is a type I membrane protein that processes stromelysin-3 (MMP-11) and MT1-MMP. It cleaves pro-hormones, neuropeptide precursors, some viral proteins, and bacterial toxins.
          This preparation was subjected to UV irradiation for 5 min to inactivate any residual vaccinia virus.
          Catalogue Number344932
          Brand Family Calbiochem®
          References
          ReferencesBassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
          Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
          Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of furin that will cleave 1.0 pmol AMC from the substrate pGlu-Arg-Thr-Lys-Arg-AMC per min at 30°C, pH 7.5.
          FormLiquid
          FormulationIn 20 mM Bis-Tris buffer, 1 mg/ml BSA, pH 7.0.
          Applications
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344932

          References

          Reference overview
          Bassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
          Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
          Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-January-2008 JSW
          DescriptionRecombinant, human furin expressed in vaccinia virus (VV:hFUR713t) infected BSC-40 cells. Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like pro-hormone convertase (PC) family. Members of this family cleave pro-hormones, neuropeptide precursors, some viral proteins, and bacterial toxins. The preparation was subjected to UV irradiation for 5 minutes to inactivate any residual virus.
          FormLiquid
          FormulationIn 20 mM Bis-Tris buffer, 1 mg/ml BSA, pH 7.0.
          Unit definitionOne unit is defined as the amount of furin that will cleave 1.0 pmol AMC from the substrate pGlu-Arg-Thr-Lys-Arg-AMC per min at 30°C, pH 7.5.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesBassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
          Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
          Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.