344850 Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem

344850
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₄H₅₉NO₁₅ 116355-83-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344850-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC50 = 100 nM). Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Exhibits carcinogenic properties.
          Catalogue Number344850
          Brand Family Calbiochem®
          SynonymsFB₁
          References
          ReferencesWu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
          Riley, R.T., et al. 1994. J. Nutr. 124, 594.
          Wolf, G. 1994. Nutr. Rev. 52, 246.
          Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
          Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
          Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
          Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
          Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.
          Product Information
          CAS number116355-83-0
          ATP CompetitiveN
          FormWhite to beige powder
          Hill FormulaC₃₄H₅₉NO₁₅
          Chemical formulaC₃₄H₅₉NO₁₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetceramide synthase
          Primary Target IC<sub>50</sub>100 nM against sphingosine N-acyltransferase (ceramide synthase)
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSTZ8350000
          Safety Information
          R PhraseR: 40

          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-26-36/37/39

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344850

          References

          Reference overview
          Wu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
          Riley, R.T., et al. 1994. J. Nutr. 124, 594.
          Wolf, G. 1994. Nutr. Rev. 52, 246.
          Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
          Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
          Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
          Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
          Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.

          Citations

          Title
        • Rita Fishelevich, et al. (2006) Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation. Journal of Immunology 176, 2590-2599.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-January-2017 JSW
          SynonymsFB₁
          DescriptionFumonisin B1 is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC50 = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB1. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.
          FormWhite to beige powder
          CAS number116355-83-0
          RTECSTZ8350000
          Chemical formulaC₃₄H₅₉NO₁₅
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityMethanol (5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 4289
          ReferencesWu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
          Riley, R.T., et al. 1994. J. Nutr. 124, 594.
          Wolf, G. 1994. Nutr. Rev. 52, 246.
          Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
          Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
          Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
          Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
          Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.
          Citation
        • Rita Fishelevich, et al. (2006) Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation. Journal of Immunology 176, 2590-2599.