344847 | Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem

344847
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₅N₃O₃ 118974-02-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344847-250UG
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          Plastic ampoule 250 μg
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          Description
          OverviewA cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.
          Catalogue Number344847
          Brand Family Calbiochem®
          SynonymsNSC719655, FTC
          References
          ReferencesAllen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
          Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
          Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
          Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
          Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.
          Product Information
          CAS number118974-02-0
          ATP CompetitiveN
          FormLyophilized
          Hill FormulaC₂₂H₂₅N₃O₃
          Chemical formulaC₂₂H₂₅N₃O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationFumitremorgin C, Aspergillus. Fumigatus, CAS 118974-02-0, is a cell-permeable chemo-sensitizing agent that inhibits BCRP/ABCG2 multidrug transport activity.
          Biological Information
          Primary TargetBCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344847

          References

          Reference overview
          Allen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
          Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
          Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
          Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
          Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-May-2008 RFH
          SynonymsNSC719655, FTC
          DescriptionA cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.
          FormLyophilized
          Intert gas (Yes/No) Packaged under inert gas
          CAS number118974-02-0
          Chemical formulaC₂₂H₂₅N₃O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesAllen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
          Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
          Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
          Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
          Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.