344845 Fumagillin, Aspergillus fumigatus - CAS 23110-15-8 - Calbiochem

344845
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₃₄O₇ 23110-15-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344845-500UG
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      Stocked 
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          Plastic ampoule 500 μg
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          Description
          OverviewAntiprotozoal agent and angiogenesis inhibitor. Acts as an inhibitor of methionine amino-peptidase 2.
          Catalogue Number344845
          Brand Family Calbiochem®
          SynonymsFumidil B, MetAP-2 Inhibitor I, MetAP2 Inhibitor I, Methionine Aminopeptidase 2 Inhibitor I
          References
          ReferencesZhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
          Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
          Abrams, J.S., et al. 1994. Cancer 74, 1164.
          Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
          Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
          Molnar, K. 1993. Acta Vet. Hung. 41, 51.
          Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
          Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.
          Product Information
          CAS number23110-15-8
          ATP CompetitiveN
          FormWhite to off-white powder
          Hill FormulaC₂₆H₃₄O₇
          Chemical formulaC₂₆H₃₄O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMethionine amino-peptidase 2
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSHE1750000
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344845

          References

          Reference overview
          Zhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
          Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
          Abrams, J.S., et al. 1994. Cancer 74, 1164.
          Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
          Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
          Molnar, K. 1993. Acta Vet. Hung. 41, 51.
          Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
          Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-July-2017 JSW
          SynonymsFumidil B, MetAP-2 Inhibitor I, MetAP2 Inhibitor I, Methionine Aminopeptidase 2 Inhibitor I
          DescriptionAn inhibitor of angiogenesis. Has selective cytostatic effects against ras transformed cells (IC50 = 10 pM). Antiprotozoal agent active against sporozoan parasites in bees and myxozoan parasites in fish.
          FormWhite to off-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number23110-15-8
          RTECSHE1750000
          Chemical formulaC₂₆H₃₄O₇
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityMethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Harmful
          Merck USA index14, 4286
          ReferencesZhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
          Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
          Abrams, J.S., et al. 1994. Cancer 74, 1164.
          Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
          Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
          Molnar, K. 1993. Acta Vet. Hung. 41, 51.
          Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
          Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.