344282 Forskolin, Coleus forskohlii in DMSO - Calbiochem

344282
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₃₄O₇

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344282-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. The solid form of this compound (Cat. No. 344270) is also available.
          Catalogue Number344282
          Brand Family Calbiochem®
          References
          ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
          Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Galli, C., et al. 1995. J. Neurosci. 15, 1172.
          Li, X., et al. 1995. Am. J. Physiol. 269, C986.
          Lomo, J., et al. 1995. J. Immunol. 154, 1634.
          Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
          Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
          Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
          Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
          Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
          Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
          Product Information
          FormLiquid
          FormulationA 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.
          Hill FormulaC₂₂H₃₄O₇
          Chemical formulaC₂₂H₃₄O₇
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344282

          References

          Reference overview
          D'Orazio, J.A., et al. 2006. Nature 443, 340.
          Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Galli, C., et al. 1995. J. Neurosci. 15, 1172.
          Li, X., et al. 1995. Am. J. Physiol. 269, C986.
          Lomo, J., et al. 1995. J. Immunol. 154, 1634.
          Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
          Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
          Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
          Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
          Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
          Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-February-2012 RFH
          DescriptionThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
          FormLiquid
          FormulationA 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₃₄O₇
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
          Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Galli, C., et al. 1995. J. Neurosci. 15, 1172.
          Li, X., et al. 1995. Am. J. Physiol. 269, C986.
          Lomo, J., et al. 1995. J. Immunol. 154, 1634.
          Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
          Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
          Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
          Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
          Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
          Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.