344085 | Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem

344085
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₆H₇₅NO₁₄ 80890-47-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344085-10UG
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          Alu drum 10 μg
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          Description
          OverviewA highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.
          Catalogue Number344085
          Brand Family Calbiochem®
          SynonymsConcanamycin A
          References
          ReferencesKane, M.D., et al. 1999. J. Neurochem. 72, 1939.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
          Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
          Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.
          Product Information
          CAS number80890-47-7
          ATP CompetitiveN
          FormLyophilized solid
          Hill FormulaC₄₆H₇₅NO₁₄
          Chemical formulaC₄₆H₇₅NO₁₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetVacuolar-type H+-ATPase
          Primary Target K<sub>i</sub>20 pM against vacuolar-type H+-ATPase
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLP5970000
          Safety Information
          R PhraseR: 28-37

          Very toxic if swallowed.
          Irritating to respiratory system.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344085

          References

          Reference overview
          Kane, M.D., et al. 1999. J. Neurochem. 72, 1939.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
          Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
          Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-June-2008 RFH
          SynonymsConcanamycin A
          DescriptionA highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.
          FormLyophilized solid
          CAS number80890-47-7
          RTECSLP5970000
          Chemical formulaC₄₆H₇₅NO₁₄
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO. Further dilute with aqueous buffers just prior to use.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
          Toxicity Highly Toxic
          ReferencesKane, M.D., et al. 1999. J. Neurochem. 72, 1939.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
          Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
          Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.