344095 Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

344095
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₅FNNaO₄ 93957-55-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344095-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA synthetic HMG-CoA reductase inhibitor (IC50 = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic agent. Decreases the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Inhibits the formation of TBA-reactive substances in Fe(II)-supported peroxidation of liposomes (IC50 = 12 µM). Also available as a 10 mM solution in H2O(Cat. No. 344096).
          Catalogue Number344095
          Brand Family Calbiochem®
          Synonyms(±)-(3Rʹ,5Sʹ,6E)-7-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxy-6-heptenoate, sodium
          References
          ReferencesYamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
          Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
          Ikeda, U., et al. 2000. Hypertension 36, 325.
          Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
          Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
          Yuan, J., et al. 1991. Atherosclerosis 87, 147.
          Product Information
          CAS number93957-55-2
          ATP CompetitiveN
          FormLight yellow solid
          Hill FormulaC₂₄H₂₅FNNaO₄
          Chemical formulaC₂₄H₂₅FNNaO₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHMG-CoA reductase
          Primary Target IC<sub>50</sub>40-100 nM against HMG-CoA reductase in human liver microsomes
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMJ9675050
          Safety Information
          R PhraseR: 62-63

          Possible risk of impaired fertility.
          Possible risk of harm to the unborn child.
          S PhraseS: 22-24/25-36/37/39-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344095

          References

          Reference overview
          Yamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
          Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
          Ikeda, U., et al. 2000. Hypertension 36, 325.
          Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
          Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
          Yuan, J., et al. 1991. Atherosclerosis 87, 147.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-January-2011 RFH
          Synonyms(±)-(3Rʹ,5Sʹ,6E)-7-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxy-6-heptenoate, sodium
          DescriptionA synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealky-lation and b-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number93957-55-2
          RTECSMJ9675050
          Chemical formulaC₂₄H₂₅FNNaO₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (30 mg/ml), DMSO, or Methanol
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 4218
          ReferencesYamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
          Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
          Ikeda, U., et al. 2000. Hypertension 36, 325.
          Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
          Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
          Yuan, J., et al. 1991. Atherosclerosis 87, 147.