341494 | Ferrostatin-1 - Calbiochem

341494
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341494-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable 3,4-diaminoethylbenzoate-based antioxidant that effectively prevents Glutamate- (5 mM; 3 h) induced neurotoxicity in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus; [Fer-1] = 2 µM, added 0.5 h prior to Glutamate) and Erastin- (Cat. No. 329600; 50 µM; 24 h) induced HT-1080 death (EC50 = 60 nM) by blocking cytosolic and lipid ROS accumulation (by >80% at 0.5 µM in 10 µM Erastin-treated HT-1080 cells). Fer-1 does not prevent H2O2- (Cat. No. 386790) induced necrosis, STS- (Cat. Nos. 569396 & 569397) induced apoptosis, or Iron-independent oxidative death by Rotenone (Cat. No. 557368).
          Catalogue Number341494
          Brand Family Calbiochem®
          SynonymsFerrostatin1, Ethyl-3-amino-4-(cyclohexylamino)benzoate
          References
          ReferencesSkouta, R., et al. 2014. J. Am. Chem. Soc. 136, In press.
          Dixon, S.J., et al. 2012. Cell 149, 1060.
          Product Information
          FormTan solid
          Hill FormulaC₁₅H₂₂N₂O₂
          Chemical formulaC₁₅H₂₂N₂O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetFree radical scavenger
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Skouta, R., et al. 2014. J. Am. Chem. Soc. 136, In press.
          Dixon, S.J., et al. 2012. Cell 149, 1060.

          Brochure

          Title
          Pathways and Biomarkers of Oxidative Stress (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2013 JSW
          SynonymsFerrostatin1, Ethyl-3-amino-4-(cyclohexylamino)benzoate
          DescriptionA cell-permeable 3,4-diaminoethylbenzoate-based antioxidant ([DPPH]t=10 min/[DPPH]t=0 = 18.8 µM/50 µM; [Fer-1]t=0 = 50 µM) that effectively prevents Glutamate- (5 mM; 3 h) induced neurotoxicity (by PI staining 24 h after glutamate removal) in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus; [Fer-1] = 2 µM, added 0.5 h prior to Glutamate) and Erastin- (Cat. No. 329600; 50 µM; 24 h) induced HT-1080 death (EC50 = 60 nM) by blocking both cytosolic and lipid ROS accumulation (by >80% in 10 µM Erastin-treated HT-1080 cells; [Fer-1] = 0.5 µM) as assessed by ROS probes H2DCFDA (Cat. No. 287810) and C11-BODIPY, respectively. Fer-1 does not prevent H2O2- (Cat. No. 386790) induced necrosis, STS- (Cat. Nos. 569396 & 569397) induced apoptosis, or Iron-independent oxidative death by Rotenone (Cat. No. 557368).
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅H₂₂N₂O₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSkouta, R., et al. 2014. J. Am. Chem. Soc. 136, In press.
          Dixon, S.J., et al. 2012. Cell 149, 1060.