533684 Ferroptosis Inhibitor, Liproxstatin-1 - Calbiochem

533684
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₉H₂₁ClN₄·HCl

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.33684.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable spiroquinoxalinamine derivative that specifically suppresses ferroptosis in glutathione peroxidase 4 (Gpx4) knockout cells (IC50 = 22 nM) and in Gpx -/- mice. However, it does not affect apoptosis induced by TNF-α, vinblatine, paclitaxel, and other anti-tumor agents and has no effect on H2O2 induced necrosis. Protects primary human renal proximal tubule epithelial cells from RSL3-induced cell death (~100 nM) and extends the survival in a murine model of acute renal failure (10 mg/kg, i.p.). Reduces tissue injury in an ischaemia/reperfusion-induced hepatic damage model. Exhibits favorable pharmacokinetic profile (t 1/2 = 4.6 h; total clearance of 66 ml/min/kg) without displaying any cytotoxicity (TC50 = 6 µM in HepG2 cells).

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number533684
          Brand Family Calbiochem®
          SynonymsN-(3-chlorobenzyl)-1ʹH-spiro[piperidine-4,2ʹ-quinoxalin]-3ʹ-amine hydrochloride
          References
          ReferencesFriedmann, A., et al. 2014. PNAS. 16, 1180.
          Product Information
          FormPink powder
          Hill FormulaC₁₉H₂₁ClN₄·HCl
          Chemical formulaC₁₉H₂₁ClN₄·HCl
          ReversibleY
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ferroptosis Inhibitor, Liproxstatin-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Friedmann, A., et al. 2014. PNAS. 16, 1180.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-November-2015 JSw
          SynonymsN-(3-chlorobenzyl)-1ʹH-spiro[piperidine-4,2ʹ-quinoxalin]-3ʹ-amine hydrochloride
          DescriptionA cell-permeable spiroquinoxalinamine derivative that specifically suppresses ferroptosis in glutathione peroxidase 4 (Gpx4) knockout cells (IC50 = 22 nM) and in Gpx -/- mice. However, it does not affect apoptosis induced by TNF-α, vinblatine, paclitaxel, and other anti-tumor agents and has no effect on H2O2 induced necrosis. Protects primary human renal proximal tubule epithelial cells from RSL3-induced cell death (~100 nM) and extends the survival in a murine model of acute renal failure (10 mg/kg, i.p.). Reduces tissue injury in an ischaemia/reperfusion-induced hepatic damage model. Exhibits favorable pharmacokinetic profile (t 1/2 = 4.6 h; total clearance of 66 ml/min/kg) without displaying any cytotoxicity (TC50 = 6 µM in HepG2 cells).
          FormPink powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₉H₂₁ClN₄·HCl
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or H₂O (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFriedmann, A., et al. 2014. PNAS. 16, 1180.