341262 Factor B, Human

341262
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341262-250UG
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          Plastic ampoule 250 μg
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          Description
          OverviewNative factor B from human serum. Single-chain glycoprotein present in normal human serum at about 200 µg/ml. During activation of complement via the alternative pathway, Factor B is cleaved and thus activated by Factor D into two fragments of M.W. of 30 kDa (Ba) and 63 kDa (Bb). The Bb fragment contains the serine protease enzymatic active site. The activated Bb fragment continues activation via the alternative pathway by cleaving, and thus activating, C3 and C5.
          Catalogue Number341262
          Brand Family Calbiochem®
          SynonymsC3 Proactivator
          References
          ReferencesKam, C.M., et al. 1987. J. Biol. Chem. 262, 3444.
          Gotze, O. and Muller-Eberhard, H.J. 1971. J. Exp. Med. 134, 90s.
          Product Information
          FormLiquid
          FormulationIn PBS, pH 7.2.
          Applications
          Biological Information
          Biological activity≥1,200 Factor BH50 units/mg; ≥50% of Factor B activity in NHS (mg/mg basis)
          Purity≥90% by SDS-PAGE
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Physicochemical Information
          ContaminantsIgG, IgA, IgM, C3, C4, Factor H, Factor I, or albumin (Ouchterlony): ≤trace amounts
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341262

          References

          Reference overview
          Kam, C.M., et al. 1987. J. Biol. Chem. 262, 3444.
          Gotze, O. and Muller-Eberhard, H.J. 1971. J. Exp. Med. 134, 90s.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2008 RFH
          SynonymsC3 Proactivator
          DescriptionNative factor B from human serum. Single-chain glycoprotein present in normal human serum at about 200 µg/ml. During activation of complement via the alternative pathway, Factor B is cleaved, and thus activated by Factor D into two fragments of M.W. of ~30 kDa (Ba) and ~63 kDa (Bb). The Bb fragment contains the serine protease enzymatic active site. The activated Bb fragment continues activation via the alternative pathway by cleaving, and thus activating, C3 and C5.
          FormLiquid
          FormulationIn PBS, pH 7.2.
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Purity≥90% by SDS-PAGE
          ContaminantsIgG, IgA, IgM, C3, C4, Factor H, Factor I, or albumin (Ouchterlony): ≤trace amounts
          Biological activity≥1,200 Factor BH50 units/mg; ≥50% of Factor B activity in NHS (mg/mg basis)
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesKam, C.M., et al. 1987. J. Biol. Chem. 262, 3444.
          Gotze, O. and Muller-Eberhard, H.J. 1971. J. Exp. Med. 134, 90s.