341249 | FAAH Inhibitor II - CAS 546141-08-6 - Calbiochem

341249
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₂N₂O₃ 546141-08-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341249-5MG
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          Alu drum 5 mg
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          Description
          OverviewA cell-permeable carbamate compound that acts as a potent, selective, and irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.6 nM in brain membranes). Shown to block anandamide (Cat. No. 172100) breakdown in rat cortical neurons (IC50 = 500 pM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases (IC50 > 30 µM), including AChE (acetylcholinesterase), BCh (butyrylcholinesterase) and MGL (monoglyceride lipase). It also does not interfere with the binding of anandamide to cannabinoid receptors CB1 and CB2 (IC50 > 100 µM), as well as several ion-channels and neurotransmitter transporters.
          Catalogue Number341249
          Brand Family Calbiochem®
          SynonymsURB597, Cyclohexylcarbamic acid-3ʹ-carbamoyl-biphenyl-3-yl Ester, 3ʹ-Carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
          References
          ReferencesKathuria, S., et al. 2003. Nat. Med. 9, 76.
          Product Information
          CAS number546141-08-6
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₂₀H₂₂N₂O₃
          Chemical formulaC₂₀H₂₂N₂O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetFAAH
          Primary Target IC<sub>50</sub>4.6 nM against FAAH
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot, purge with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341249

          References

          Reference overview
          Kathuria, S., et al. 2003. Nat. Med. 9, 76.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-October-2009 JSW
          SynonymsURB597, Cyclohexylcarbamic acid-3ʹ-carbamoyl-biphenyl-3-yl Ester, 3ʹ-Carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
          DescriptionA cell-permeable, carbamate compound that acts as a potent, selective, and irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.6 nM in brain membranes). Shown to block anandamide (Cat. No. 172100) breakdown in rat cortical neurons (IC50 = 0.5 nM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases, namely, AchE (acetyl cholinesterase) (IC50 > 100 µM), BCh (butyryl cholinesterase) (IC50 > 100 µM), and MGL (monoglyceride lipase) (IC50 > 30 µM). Does not interfere with the binding of anandamide to cannabinoid receptors, CB1 and CB2 (IC50 > 100 µM), several ion-channels, or neurotransmitter transporters.
          FormWhite crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number546141-08-6
          Chemical formulaC₂₀H₂₂N₂O₃
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityEtOH (1 mg/ml), DMSO (10 mg/ml), or DMF (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot, purge with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Toxic
          ReferencesKathuria, S., et al. 2003. Nat. Med. 9, 76.