531042 Estrogen Receptor Antagonist, ICI 182,780 - CAS 129453-61-8 - Calbiochem

531042
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₄₇F₅O₃S 129453-61-8

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31042.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531042
          Brand Family Calbiochem®
          SynonymsGPR30 Agonist, ICI 182,780, ICI 182780, ICI182780
          References
          ReferencesWakeling, A. E., et al. 1991. Cancer Res. 51, 3867.
          Dauvois, S., et al. 1993. J. Cell. Sci. 106, 1377.
          Howell, A., et al. 1995. The Lancet. 8941, 29.
          Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol. 79, 209.
          Product Information
          CAS number129453-61-8
          DeclarationSold with the permission of AstraZeneca UK. Limited for research purposes only.
          FormWhite powder
          Hill FormulaC₃₂H₄₇F₅O₃S
          Chemical formulaC₃₂H₄₇F₅O₃S
          ReversibleY
          Applications
          Biological Information
          Primary TargetER
          Secondary targetGPR30
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Estrogen Receptor Antagonist, ICI 182,780 - CAS 129453-61-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Wakeling, A. E., et al. 1991. Cancer Res. 51, 3867.
          Dauvois, S., et al. 1993. J. Cell. Sci. 106, 1377.
          Howell, A., et al. 1995. The Lancet. 8941, 29.
          Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol. 79, 209.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-August-2014 JSW
          SynonymsGPR30 Agonist, ICI 182,780, ICI 182780, ICI182780
          DescriptionA cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number129453-61-8
          Chemical formulaC₃₂H₄₇F₅O₃S
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWakeling, A. E., et al. 1991. Cancer Res. 51, 3867.
          Dauvois, S., et al. 1993. J. Cell. Sci. 106, 1377.
          Howell, A., et al. 1995. The Lancet. 8941, 29.
          Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol. 79, 209.