324693 Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem

324693
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₄₀N₂O₄ · 2HCl 316-42-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324693-250MG
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          Alu drum 250 mg
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          Description
          OverviewPrincipal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
          Catalogue Number324693
          Brand Family Calbiochem®
          Synonyms6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
          References
          ReferencesKong, H.S., et al. 2010. Mol. Pharmacol. in press.
          Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
          Kokuho, T., et al. 1995. Immunobiology 193, 42.
          Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
          Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
          Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
          Landis, R.C., et al. 1991. J. Immunol. 146, 128.
          Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
          Product Information
          CAS number316-42-7
          ATP CompetitiveN
          FormWhite solid with a faint yellow cast
          Hill FormulaC₂₉H₄₀N₂O₄ · 2HCl
          Chemical formulaC₂₉H₄₀N₂O₄ · 2HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMovement of ribosomes along the mRNA
          Primary Target IC<sub>50</sub>≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSJY5250000
          Safety Information
          R PhraseR: 28-36/38

          Very toxic if swallowed.
          Irritating to eyes and skin.
          S PhraseS: 28-36/37-45


          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324693

          References

          Reference overview
          Kong, H.S., et al. 2010. Mol. Pharmacol. in press.
          Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
          Kokuho, T., et al. 1995. Immunobiology 193, 42.
          Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
          Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
          Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
          Landis, R.C., et al. 1991. J. Immunol. 146, 128.
          Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-June-2018 JSW
          Synonyms6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
          DescriptionPrinciple alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
          FormWhite solid with a faint yellow cast
          CAS number316-42-7
          RTECSJY5250000
          Chemical formulaC₂₉H₄₀N₂O₄ · 2HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol or H₂O (20 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Highly Toxic
          Merck USA index14, 3559
          ReferencesKong, H.S., et al. 2010. Mol. Pharmacol. in press.
          Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
          Kokuho, T., et al. 1995. Immunobiology 193, 42.
          Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
          Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
          Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
          Landis, R.C., et al. 1991. J. Immunol. 146, 128.
          Schweighoffer, T., et al. 1991. Histochemistry 96, 93.