434741 ETYA - CAS 1191-85-1 - Calbiochem

434741
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₄O₂ 1191-85-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      434741-20MG
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          Plastic ampoule 20 mg
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          Description
          OverviewCell permeable. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Inhibits cyclooxygenase (ID50 = 8 µM), 5-lipoxygenase (ID50 = 10 µM), 12-lipoxygenase (ID50 = 300 nM), and 15-lipoxygenase (ID50 = 200 nM) in whole cells. Also acts as a potent modulator of Ca2+ entry into cells. Blocks monocyte binding in minimally-oxidized LDL in endothelial cells. Stimulates luteinizing hormone release from cultured pituitary cells.
          Catalogue Number434741
          Brand Family Calbiochem®
          Synonyms5,8,11,14-Eicosatetraynoic Acid
          References
          ReferencesHonda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
          Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
          Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
          Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.
          Product Information
          CAS number1191-85-1
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₀H₂₄O₂
          Chemical formulaC₂₀H₂₄O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPLA₂
          Primary Target IC<sub>50</sub>8 µM, 10 µM, 300 nM, 200 nM against cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase , respectively, in whole cells
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          434741

          References

          Reference overview
          Honda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
          Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
          Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
          Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-August-2008 RFH
          Synonyms5,8,11,14-Eicosatetraynoic Acid
          DescriptionCell-permeable. Inhibits arachidonic acid uptake and arachidonic acid specific and nonspecific acyl-CoA synthesis. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Inhibits cyclooxygenase (ID50 = 8 µM), 5-lipoxygenase (ID50 = 10 µM), 12-lipoxygenase (ID50 = 300 nM), and 15-lipoxygenase (ID50 = 200 nM) in whole cells. A potent modulator of Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells.
          FormOff-white solid
          CAS number1191-85-1
          Chemical formulaC₂₀H₂₄O₂
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO or Ethanol (20 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHonda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
          Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
          Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
          Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.