328009 | ERK Inhibitor III - CAS 331656-92-9 - Calbiochem

328009
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₁₀N₆O₅ 331656-92-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      328009-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD = ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
          Catalogue Number328009
          Brand Family Calbiochem®
          References
          ReferencesChen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.
          Product Information
          CAS number331656-92-9
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₂H₁₀N₆O₅
          Chemical formulaC₁₂H₁₀N₆O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetERK
          Primary Target IC<sub>50</sub>KD = ~13 µM against ERK
          Purity≥85% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          328009

          References

          Reference overview
          Chen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.

          Brochure

          Title
          Biologics 33.1 ( 1.37 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2011 RFH
          DescriptionA cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD of ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number331656-92-9
          Chemical formulaC₁₂H₁₀N₆O₅
          Structure formulaStructure formula
          Purity≥85% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesChen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.