324890 E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem

324890
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₂₇N₅O₅ 66701-25-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324890-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          324890-25MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              Glass bottle 25 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              324890-5MG
              Retrieving availability...
              Limited AvailabilityLimited Availability
              Stocked 
              Discontinued
              Limited Quantities Available
              Available
                Remaining : Will advise
                  Remaining : Will advise
                  Will advise
                  Contact Customer Service
                  Contact Customer Service

                  Plastic ampoule 5 mg
                  Retrieving price...
                  Price could not be retrieved
                  Minimum Quantity needs to be mulitiple of
                  Upon Order Completion More Information
                  You Saved ()
                   
                  Request Pricing
                  Description
                  OverviewIrreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
                  Catalogue Number324890
                  Brand Family Calbiochem®
                  Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
                  References
                  ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
                  Sarin, A., et al. 1994. J. Immunol. 153, 862.
                  Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
                  Barrett, A.J. 1982. Biochem. J. 201, 189.
                  Product Information
                  CAS number66701-25-5
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₁₅H₂₇N₅O₅
                  Chemical formulaC₁₅H₂₇N₅O₅
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Applications
                  ApplicationE-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.
                  Biological Information
                  Primary Targetcysteine proteases
                  Purity≥98% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSRR0390000
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  324890

                  References

                  Reference overview
                  Matsumoto, K., et al. 1999. Biopolymers 51, 99.
                  Sarin, A., et al. 1994. J. Immunol. 153, 862.
                  Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
                  Barrett, A.J. 1982. Biochem. J. 201, 189.

                  Brochure

                  Title
                  Protease and Phosphatase Inhibitor Cocktails Brochure

                  Citations

                  Title
                • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision12-July-2013 JSW
                  Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
                  DescriptionIrreversible inhibitor of cysteine proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
                  FormWhite solid
                  CAS number66701-25-5
                  RTECSRR0390000
                  Chemical formulaC₁₅H₂₇N₅O₅
                  Structure formulaStructure formula
                  Purity≥98% by HPLC
                  SolubilityDMSO (25 mg/ml) or H₂O (20 mg/ml)
                  Storage -20°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
                  Toxicity Standard Handling
                  ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
                  Sarin, A., et al. 1994. J. Immunol. 153, 862.
                  Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
                  Barrett, A.J. 1982. Biochem. J. 201, 189.
                  Citation
                • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.