324380 | Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem

324380
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₂₉NO₁₁ · HCl 25316-40-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324380-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewAntitumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, thereby inhibiting nucleic acid synthesis. Induces apoptosis in rhabdomyosarcoma cell lines. Also available as a 10 mM solution in H2O (Cat. No. 504042).
          Catalogue Number324380
          Brand Family Calbiochem®
          SynonymsAdriamycin, 14-Hydroxydaunomycin, HCl
          References
          ReferencesA'Hern, R.P., and Gore, M.E. 1995. J. Clin. Oncol. 13, 726.
          Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
          Noviello, E., et al. 1994. Mutat. Res. 311, 21.
          Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
          Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
          Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
          O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
          Theyer, G., et al. 1993. J. Urol. 150, 1544.
          Tritton, T.R., and Yee, G. 1982. Science 217, 248.
          Product Information
          CAS number25316-40-9
          ATP CompetitiveN
          FormOrange to red powder
          Hill FormulaC₂₇H₂₉NO₁₁ · HCl
          Chemical formulaC₂₇H₂₉NO₁₁ · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targettopoisomerase 2
          Primary Target IC<sub>50</sub>100 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQI9295900
          Safety Information
          R PhraseR: 45-46

          May cause cancer.
          May cause heritable genetic damage.
          S PhraseS: 36/37-45-53-22-28

          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Do not breathe dust.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C. Under acidic conditions doxorubicin is converted to a water-insoluble adriamycinone and a water soluble reducing sugar, daunosamine.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324380

          References

          Reference overview
          A'Hern, R.P., and Gore, M.E. 1995. J. Clin. Oncol. 13, 726.
          Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
          Noviello, E., et al. 1994. Mutat. Res. 311, 21.
          Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
          Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
          Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
          O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
          Theyer, G., et al. 1993. J. Urol. 150, 1544.
          Tritton, T.R., and Yee, G. 1982. Science 217, 248.

          Brochure

          Title
          Antibiotics Profiler
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-May-2018 JSW
          SynonymsAdriamycin, 14-Hydroxydaunomycin, HCl
          DescriptionAn anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.
          FormOrange to red powder
          CAS number25316-40-9
          RTECSQI9295900
          Chemical formulaC₂₇H₂₉NO₁₁ · HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (10 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C. Under acidic conditions doxorubicin is converted to a water-insoluble adriamycinone and a water soluble reducing sugar, daunosamine.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 3439
          ReferencesA'Hern, R.P., and Gore, M.E. 1995. J. Clin. Oncol. 13, 726.
          Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
          Noviello, E., et al. 1994. Mutat. Res. 311, 21.
          Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
          Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
          Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
          O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
          Theyer, G., et al. 1993. J. Urol. 150, 1544.
          Tritton, T.R., and Yee, G. 1982. Science 217, 248.