530463 Dopamine Receptor D3 Antagonist II, YQA14 - Calbiochem

530463
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₂₇ClN₄O₃

      Pricing & Availability

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      5.30463.0001
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          Glass bottle 10 mg
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          Description
          OverviewAn orally bioavailable benzoxazolone carboxamide derivative that acts as a highly potent and selective antagonist of dopamine D3 receptors. Has two binding sites on human cloned D3 receptors (Ki = 0.0680 pM high affinity and 2.11 nM low affinity). Displays >150-fold greater selectivity for D3 over D2 receptors and about 1000-fold selectivity over other dopamine receptors. Exhibits strong anti-addiction profile and reduces self administration of cocaine in rodent models (6.25 to 25 mg/kg in rats) without affecting their sucrose water self-administration and locomotor activity.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number530463
          Brand Family Calbiochem®
          SynonymsD3R Antagonist
          References
          ReferencesSong, R., et al. 2014. Neuropharm. 77, 398.
          Song, R., et al. 2011. Addiction Biol. 17, 259.
          Product Information
          FormTan powder
          Hill FormulaC₂₃H₂₇ClN₄O₃
          Chemical formulaC₂₃H₂₇ClN₄O₃
          Applications
          Biological Information
          Primary TargetD3
          Primary Target K<sub>i</sub>0.068 pM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Dopamine Receptor D3 Antagonist II, YQA14 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Song, R., et al. 2014. Neuropharm. 77, 398.
          Song, R., et al. 2011. Addiction Biol. 17, 259.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-June-2014 JSW
          SynonymsD3R Antagonist
          DescriptionAn orally bioavailable benzoxazolone carboxamide derivative that acts as a highly potent and selective antagonist of dopamine D3 receptors. Has two binding sites on human cloned D3 receptors (Ki = 0.0680 pM high affinity and 2.11 nM low affinity). Displays >150-fold greater selectivity for D3 over D2 receptors and about 1000-fold selectivity over other dopamine receptors. Exhibits strong anti-addiction profile and reduces self administration of cocaine in rodent models (6.25 to 25 mg/kg in rats) without affecting their sucrose water self-administration and locomotor activity.
          FormTan powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₂₇ClN₄O₃
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C
          Toxicity Standard Handling
          ReferencesSong, R., et al. 2014. Neuropharm. 77, 398.
          Song, R., et al. 2011. Addiction Biol. 17, 259.