532383 Donecopride Fumarate - Calbiochem

532383
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₃₃ClN₂O₂·C₄H₄O₄·xH₂O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.32383.0001
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          Glass bottle 5 mg
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          Description
          OverviewA cell permeable, brain penetrating piperidin-4-yl-propanone compound that that acts as a highly potent, selective and partial agonist of serotonin subtype 4 receptor ((h)5-HT4R; Ki = 10.4 nM and 48% efficacy compared to 5-HT control). Also acts as a potent, mixed type, competitive inhibitor of acetylcholinesterase (IC50 = 16 nM for human AChE) and offers selectivity over butyrylcholinesterase (IC50 = 3.5 µM). With respect to 5-HT2BR, it behaves like an inverse agonist (Ki = 1.6 nM). Promotes sAPPα secretion in COS-7 cells transiently expressing 5-HT4R (EC50 = 11.3 nM) and is shown to have a precognitive effect in murine model where it significantly improves discrimination index (6.3 vs -.0.22 in control mice; 0.3 mg/kg).

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number532383
          Brand Family Calbiochem®
          Synonyms5-HT4R Agonist, AChE Inhibitor, MR31147, Serotonin receptor 5-HT4R agonist
          References
          ReferencesLecoutey, C., et al. 2014. Proc. Natl. Acad. Sci. USA 111, E3825.
          Product Information
          FormOff-white powder
          Hill FormulaC₂₂H₃₃ClN₂O₂·C₄H₄O₄·xH₂O
          Chemical formulaC₂₂H₃₃ClN₂O₂·C₄H₄O₄·xH₂O
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary Target5-HT4R
          Primary Target K<sub>i</sub>10.4 nM
          Secondary targetAChE
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Donecopride Fumarate - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Lecoutey, C., et al. 2014. Proc. Natl. Acad. Sci. USA 111, E3825.

          Brochure

          Title
          Neuroscience Solutions for productive research

          Technical Info

          Title
          Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-March-2015 JSW
          Synonyms5-HT4R Agonist, AChE Inhibitor, MR31147, Serotonin receptor 5-HT4R agonist
          DescriptionA cell permeable, brain penetrating piperidin-4-yl-propanone compound that that acts as a highly potent, selective and partial agonist of serotonin subtype 4 receptor ((h)5-HT4R; Ki = 10.4 nM and 48% efficacy compared to 5-HT control). Also acts as a potent, mixed type, competitive inhibitor of acetylcholinesterase (IC50 = 16 nM for human AChE) and offers selectivity over butyrylcholinesterase (IC50 = 3.5 µM). With respect to 5-HT2BR, it behaves like an inverse agonist (Ki = 1.6 nM). Promotes sAPPα secretion in COS-7 cells transiently expressing 5-HT4R (EC50 = 11.3 nM) and is shown to have a precognitive effect in murine model where it significantly improves discrimination index (6.3 vs -.0.22 in control mice; 0.3 mg/kg).
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₃₃ClN₂O₂·C₄H₄O₄·xH₂O
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLecoutey, C., et al. 2014. Proc. Natl. Acad. Sci. USA 111, E3825.