324378 Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem

324378
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₂₁NO₆ 14277-97-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324378-1MG
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          Plastic ampoule 1 mg
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          Description
          Overview

          This product has been discontinued.



          A heat-stable neurotoxin. Glutamate kainate receptor agonist that shows higher affinity for the kainate receptor than any other known kainic acid analog. Causes excessive excitation of neurons resulting in the depletion of energy stores, cellular edema, and death. Inhibits adenylate cyclase activity in neuronal membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.

          Catalogue Number324378
          Brand Family Calbiochem®
          Synonyms25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid
          References
          ReferencesAlfonso, M., et al. 1994. Neurochem. Int. 24, 267.
          Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
          Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
          Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
          Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
          Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
          Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
          Wright, P., et al. 1989. Can. J. Chem. 67, 481.
          Product Information
          CAS number14277-97-5
          ATP CompetitiveN
          FormWhite to off-white crystaline solid
          Hill FormulaC₁₅H₂₁NO₆
          Chemical formulaC₁₅H₂₁NO₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGlutamate kainate receptor
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUX9665100
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Do not freeze solutions. Stock solutions are stable for up to 24 h at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324378

          References

          Reference overview
          Alfonso, M., et al. 1994. Neurochem. Int. 24, 267.
          Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
          Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
          Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
          Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
          Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
          Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
          Wright, P., et al. 1989. Can. J. Chem. 67, 481.

          Brochure

          Title
          Excitotoxic Glutamate Analogs Technical Bulletin
          Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-May-2008 RFH
          Synonyms25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid
          DescriptionGlutamate kainate excitatory amino acid agonist with the highest affinity for the kainate receptor of all known kainic acid analogs. It has been used to purify the kainate receptor by affinity chromatography. Its binding to the receptor causes continuous stimulation of nerve cells leading to depletion of energy, cellular edema, and death. Its neurological effect resembles anterograde memory loss associated with Alzheimer's disease. Inhibits adenylate cyclase activity in brain membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
          FormWhite to off-white crystaline solid
          CAS number14277-97-5
          RTECSUX9665100
          Chemical formulaC₁₅H₂₁NO₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (8 mg/ml) or Methanol (0.6 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Do not freeze solutions. Stock solutions are stable for up to 24 h at 4°C.
          Toxicity Harmful
          Merck USA index14, 3417
          ReferencesAlfonso, M., et al. 1994. Neurochem. Int. 24, 267.
          Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
          Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
          Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
          Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
          Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
          Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
          Wright, P., et al. 1989. Can. J. Chem. 67, 481.