266788 Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem

266788
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₅F₂N₃OS 120166-69-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      266788-5MG
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          Glass bottle 5 mg
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          Description
          OverviewInhibits diacylglycerol kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM) by binding to the catalytic domain. A more potent analog of diacylglycerol kinase inhibitor I (Cat. No. 266785).
          Catalogue Number266788
          Brand Family Calbiochem®
          SynonymsR59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
          References
          ReferencesJiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
          Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
          Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
          de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.
          Product Information
          CAS number120166-69-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₈H₂₅F₂N₃OS
          Chemical formulaC₂₈H₂₅F₂N₃OS
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDiacylglycerol Kinase
          Primary Target IC<sub>50</sub>300 nM and 120 nM against diacylglycerol kinase in isolated platelet membranes and in intact platelets, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          266788

          References

          Reference overview
          Jiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
          Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
          Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
          de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.

          Citations

          Title
        • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
        • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-March-2009 RFH
          SynonymsR59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
          DescriptionInhibitor useful for elucidating roles of protein kinase C. Inhibits diacylglycerol (DAG) kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM). A more potent analog of DAG kinase inhibitor I.
          FormWhite solid
          CAS number120166-69-0
          Chemical formulaC₂₈H₂₅F₂N₃OS
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (12.5 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesJiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
          Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
          Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
          de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.
          Citation
        • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
        • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.